Threats of Concomitant Use or Discontinuation of Cytochrome P450 2D6 Inhibitors The concomitant utilization of tramadol hydrochloride tablets with all cytochrome P450 2D6 inhibitors (e.g., amiodarone, quinidine) may perhaps cause an increase in tramadol plasma stages in addition to a reduce while in the amounts of the Energetic metabolite, M1.Trama